Benign eyelid lesions and malignant tumors arising from skin like, basal cell carcinoma, malignant melanoma, squamous cell carcinoma.

Eyelid Lesions

Patients with eyelid lesions often present in the primary healthcare setting. Although most eyelid lumps are benign, accurate diagnosis and early recognition of sinister lesions leads to improved patient outcomes. This article will focus on benign eyelid lesions this includes arising from glands like Chalazions, and malignant tumors arising from skin like, basal cell carcinoma, malignant melanoma, squamous cell carcinoma.

The majority of eyelid lesions are benign, ranging from innocuous cysts (cysts of Moll, Zeis and epidermoid cyst) and chalazion/hordeolum to naevi and papillomas. Key features that should prompt further investigation include gradual enlargement, central ulceration or induration, irregular borders, eyelid margin destruction or loss of lashes, and telangiectasia. The presence of these features should prompt referral to an ophthalmologist for further evaluation.

Types of benign eyelid lesions

Eyelid lesions arising from glands

There are three types of glands located in the eyelids: Meibomian, Zeis and Moll. Blockage of any of these glands results in corresponding focal collections/cysts, and these are commonly encountered in general practice. Figure 1 shows some common benign lesions that occur around the eyelid.

Common benign eyelid lesions: Translucent cyst of Moll (upper left), cyst of Zeis filled with sebaceous material (upper right), epidermal inclusion cyst filled with keratin (lower left) and molluscum contagiosum (lower right)
Common benign eyelid lesions: Translucent cyst of Moll (upper left), cyst of Zeis filled with sebaceous material (upper right), epidermal inclusion cyst filled with keratin (lower left) and molluscum contagiosum (lower right)

Cysts of Moll arise from blocked apocrine sweat glands found on the margin of the eyelid. They are solitary dome-shaped papules or nodules filled with clear fluid, making transillumination a key feature.

Apocrine hidrocystomas are common smooth cysts that are considered adenomas of the secretory cells of Moll rather than classic retention cysts but clinically look similar and may have a bluish color.

Cysts of Zeis arise from blocked sebaceous glands, also found on the eyelid margin. These tend to be filled with yellow oily secretions and do not transilluminate.

Chalazions represent focal granulomatous inflammation due to retained Meibomian gland secretions from a blocked duct and are the most common lid lesion. Meibomian glands are modified sebaceous glands present throughout the upper and lower eyelid, in and around the tarsal plate. Chalazions present as painless nodules within the tarsal plate (posterior aspect of lid) or at the lid margin and can vary in size. Associated blepharitis is common, and clinical signs include eyelid margin telangiectasia, erythema and lash crusting. Symptoms tend to reflect ocular surface discomfort and can include dryness, gritty sensation and/or epiphora (watery eyes). Treatment involves hot compress, massage and eyelid margin hygiene at least twice per day. Antibiotics are not required unless there is evidence of superimposed bacterial infection. Conservative treatment is recommended for at least 1–2 months prior to referral for consideration of incision and drainage.

Benign eyelid lesions and malignant tumors arising from skin like, basal cell carcinoma, malignant melanoma, squamous cell carcinoma.
Benign eyelid lesions and malignant tumors arising from skin like, basal cell carcinoma, malignant melanoma, squamous cell carcinoma.

Hordeolums (styes) are acute bacterial infections of any of the above blocked glands and are classified as either internal (Meibomian gland) or external (Zeis or Moll). Associated preseptal cellulitis is common and can be treated with a course of oral antibiotics in addition to hot compress and massage. Orbital cellulitis is a rare but potentially sight-threatening and even life-threatening complication that occurs when infection breaches the orbital septum. Differentiating preseptal from orbital cellulitis involves examination of visual acuity, pupils, extraocular movements and the eyelids. A drop in visual acuity, relative afferent pupillary defect or sluggish pupils, painful and limited eye movements, proptosis and chemosis are suggestive of orbital cellulitis and require prompt referral to a tertiary centre emergency department for imaging and antibiotic treatment.

Epidermal eyelid lesions

Cysts of the epidermis are the second most common type of benign periocular eyelid lesions encountered.

Epidermal inclusion cysts arise from the infundibulum of the hair follicle and are primarily due to occlusion. These lesions are slow-growing, firm, elevated, round and often have a central pore. Epidermal inclusion cysts are filled with keratin (despite being sometimes called sebaceous cysts), and rupture can incite an inflammatory foreign body reaction. Secondary infection is also possible. Referral for surgical excision is generally recommended.

Molluscum contagiosum is caused by the molluscum contagiosum virus, a member of the Poxviridae family. Immunocompetent young children and patients who are immunosuppressed are more commonly affected.1 Lesions are characteristically 1–3 mm white, pink or flesh-colored nodules with a central umbilication. Molluscum contagiosum may also cause a follicular conjunctivitis because of shedding of the molluscum virus into the tear film. Treatment is usually not required as the lesions will spontaneously resolve over time. For rare cases that are very symptomatic, cryotherapy or curettage can be used, but referral to an ophthalmologist may be warranted given the locally destructive treatment modalities.

Xanthelasma are lesions in the superficial dermis and subdermal tissue containing lipid-laden macrophages. These are sometimes associated with raised cholesterol or congenital disorders of lipid metabolism requiring further investigation and management. Surgical excision can be considered for cosmetic reasons.

Xanthelasma are lesions in the superficial dermis and subdermal tissue containing lipid-laden macrophages.
Xanthelasma are lesions in the superficial dermis and subdermal tissue containing lipid-laden macrophages.
Benign tumours

Benign tumours are also known as epidermal proliferations. The term papilloma refers to a group of various benign epithelial proliferations that can affect the eyelid skin. Figure 2 shows common benign eyelid lesions.

Benign eyelid lesions and malignant tumors arising from skin like, basal cell carcinoma, malignant melanoma, squamous cell carcinoma.
upper right Papilloma , upper left eyelid nevus inflamed , lower pictures Verruca vulgaris (viral wart)

Seborrheic keratosis is the most common benign eyelid lesion that affects elderly patients and carries no risk of malignant transformation. It is most commonly described as a well-demarcated, waxy, pigmented lesion with a ‘stuck on’ appearance. However, on the eyelid, seborrheic keratoses may be lobulated or pedunculated. Excision can be considered for cosmetic purposes or if the seborrheic keratosis is large enough to interfere with vision. If there are no concerns about the eyelid structure or function being affected, excision may be performed by the general practitioner (GP).

Seborrheic keratosis is the most common benign eyelid lesion
Seborrheic keratosis is the most common benign eyelid lesion

Verruca vulgaris (viral wart) is caused by epidermal infection with human papillomavirus, typically type 6 or 11. These lesions are most commonly found at the eyelid margin as non-pigmented papules with digitations. Cryotherapy can be used to prevent viral spread, but this should be performed cautiously around the eyelid area.

Benign melanocytic lesions

Pigmentation can be seen in both benign and malignant lesions and does not necessarily imply melanocytic origin. Conversely, lesions of melanocytic origin may not be visibly pigmented (eg amelanotic naevus).

Naevi are flat or raised lesions that arise from melanocytes and are common on the eyelid. Naevi progress through three stages, starting in childhood as a junctional naevus that is a flat, pigmented macule located in the dermoepidermal junction. It then becomes an elevated compound naevus in the second decade, involving both the dermoepidermal junction and dermis, before involuting later in life and losing pigmentation by the seventh decade. Third-stage naevi are known as dermal naevi and involve the dermis only. Transformation to melanoma is rare, but can occur in junctional or compound naevi.

Vascular eyelid lesions

Infantile haemangiomas, previously known as strawberry or capillary haemangiomas, are lesions with a classic red/pink appearance that are common in children. The vast majority of these lesions involute and self-resolve by the age of 10 years. Rarely, they can cause ptosis, refractive error and amblyopia. All children with eyelid infantile haemangiomas should be referred to a paediatric ophthalmologist to assess for potential refractive error and monitor for amblyopia.3

Port wine stains are permanent capillary malformations that are present from birth. They are variably sized macular lesions that can be dark red to blue in color. The lesion grows in proportion with the child and may also gradually become raised and thicker. Port wine stains involving the eyelid may be associated with glaucoma; approximately 18% of children are affected, particularly patients with bilateral port wine stain or involvement of both upper and lower eyelids. The prevalence is further increased when associated with Sturge-Weber syndrome, with glaucoma affecting 40–60% of these patients. It is therefore important for the patient to be referred to a paediatric ophthalmologist for monitoring and regular follow-up.

Benign lesions summary

Benign lesions that should be referred include:

  • hordeolum with signs of orbital cellulitis – emergency department
  • enlarging pigmented eyelid lesion with suspicious features – urgent oculoplastics ophthalmology outpatient referral
  • eyelid infantile haemangioma or port wine stain – urgent paediatric ophthalmology outpatient referral
  • chronic chalazion that is persistent despite 2–3 months of conservative treatment – non-urgent ophthalmology outpatient referral
  • benign eyelid lesions that are cosmetically concerning – non-urgent ophthalmology or dermatology outpatient referral.


Sinister signs: When to suspect a malignant lesion

Most eyelid lesions are not malignant, but careful history-taking and examination will reveal important clues when suspecting a more sinister lesion. The eyelids are involved in 10% of cases of skin cancer, and the vast majority are basal cell carcinomas (BCC). Risk factors for developing skin cancers, as with systemic cutaneous skin cancer, include: fair skin, history of previous skin cancer, excessive sun exposure, previous radiation, immunosuppression and smoking.

Anatomically, lesions of the medial canthus are known to be more aggressive because of proximity to the lacrimal drainage system, increasing the risk of tumour spread. Eversion of the upper eyelid during examination can reveal lesions otherwise missed with an external-only exam or a more extensive lesion than initially expected. Loss of lashes and/or destruction of eyelid architecture is often a telltale sign of malignancy.

Central ulceration, especially if associated with ‘flaky’ skin, can represent the more aggressive squamous cell carcinomas (SCCs). When suspecting a malignant lesion, it is essential to examine the regional lymph nodes (preauricular in particular), as well as check sensation around the periocular area, particularly in the distribution of the infraorbital nerve for lesions of the lower eyelid or lateral canthus. Any loss of sensation may indicate perineural invasion. Also, Recurrence of a begin eyelid lesion in the same place is highly suspicious of a malignant transformation.

Benign eyelid lesions and malignant tumors arising from skin like, basal cell carcinoma, malignant melanoma, squamous cell carcinoma.
Importance of eyelid eversion: An extensive upper eyelid sebaceous carcinoma, the full extent of which can be better appreciated with eversion. This patient presented with chronic upper eyelid changes initially misdiagnosed as chalazion
Table 1. When to suspect malignancy
HistoryExam
Risk factors: prior skin cancer, fair skin, previous radiation, immunosuppression, Gradual enlargement, PainlessUlceration, Induration, Irregular or ‘pearly’ borders, Destruction of eyelid margin, Loss of lashes (madarosis), Telangiectasia, Reduced sensation

If a malignant lesion is suspected, the patient should be referred to either an oculoplastic ophthalmologist or to a tertiary care hospital for further evaluation. Where possible, a biopsy of the lesion will be performed for preoperative planning, and intraoperative margin control is preferred for any malignant lesion. Although the majority of lid lesions encountered have low metastatic potential, larger lesions are associated with more difficult reconstruction and associated ocular morbidity. Early diagnosis is key. Malignant lesions encountered are described in the following section.

Malignant eyelid tumours: A basal cell carcinoma presenting as an isolated nodule with associated telangiectasia and loss of lashes (upper left), keratoacanthoma (upper right), actinic keratosis (lower left) and invasive squamous cell carcinoma with central ulceration (lower right)
Malignant eyelid tumors: A basal cell carcinoma presenting as an isolated nodule with associated telangiectasia and loss of lashes (upper left), keratoacanthoma (upper right), actinic keratosis (lower left) and invasive squamous cell carcinoma with central ulceration (lower right)

Types of malignant eyelid lesions

Basal cell carcinoma

Basal cell carcinoma is the most common eyelid malignancy, accounting for 80–90% of cases, and are typically found on the lower eyelid or medial canthus. These are typically slow-growing, locally-destructive skin cancers with a low propensity for metastatic spread. A classical presentation of a Basal cell carcinoma is the nodular type – a smooth, pearly-edged nodule with telangiectasia. As the tumour enlarges and outgrows its nutrient supply, central tumour necrosis may occur, leaving a central ulcer.

Multiple other histological subtypes of Basal cell carcinoma have been described including morphoeic, superficial, infiltrative, micronodular and linear. Most cannot be distinguished clinically, but if initial biopsy reveals an aggressive subtype, surgical planning can be adapted accordingly. Complete surgical excision with intraoperative margin control is the gold-standard treatment for eyelid Basal cell carcinoma, regardless of histological subtype, and is associated with low rates of recurrence.

Actinic keratosis

Actinic keratosis is a common precancerous skin lesion that has potential to develop into an squamous cell carcinoma and is found on sun-damaged skin. The risk of malignant transformation is only 0.24% per year, but over an extended follow-up period, the incidence of squamous cell carcinoma in an individual with multiple actinic keratoses is as high as 12–16%. Actinic keratoses present as scaly, hyperkeratotic plaques with a sandpaper-like texture. Although they are usually treated with cryotherapy, when located on the eyelid margin, surgical excision is generally recommended. Topical imiquimod is an alternative option that requires dermatology referral.

Keratoacanthoma

Keratoacanthoma has previously been considered a benign lesion but more recently is regarded as a low-grade squamous cell carcinoma for which complete excision is recommended. It has a characteristic dome-shape with a central crater filled with keratin and may be associated with surrounding inflammatory changes.

Squamous cell carcinoma

squamous cell carcinoma accounts for approximately 5% of epithelial tumours of the eyelid but are much more aggressive than the more commonly encountered basal cell carcinoma. squamous cell carcinoma develops either spontaneously or from actinic keratosis, Bowen’s disease (squamous cell carcinoma in situ), keratoacanthomas or radiation dermatosis. They are more common in immunocompromised patients, particularly following solid organ transplant. squamous cell carcinoma can be difficult to distinguish from squamous cell carcinoma; however, they usually have more scaling and may have an adherent crust or associated ulceration. Prompt referral is required given the higher rates of regional nodal (24%), perineural (8%) and distant metastatic (6%) spread. For this reason, margin-controlled excision is the gold-standard treatment, although newer targeted therapy involving the hedgehog pathway and epidermal growth factor receptor have been promising in patients with advanced metastatic disease.

Sebaceous carcinoma

Sebaceous carcinoma is a rare but frequently misdiagnosed tumor. It accounts for 1.0–5.5% of all eyelid malignancies and was previously thought to be more common in people of Asian ethnicity, although recent evidence suggests more equal incidence across all ethnicities. Sebaceous carcinoma arises from the Meibomian glands within the tarsus and presents either as a solitary nodule or diffuse eyelid thickening, often with associated inflammatory changes. Anatomically, given the similarities with chalazion, these lesions are often misdiagnosed initially.

Although sebaceous carcinomas are rare, any chronic chalazion associated with a gradual increase in size or persistent, diffuse eyelid inflammation and associated thickening (sometimes only evident with eyelid eversion) should raise suspicion. These tumours are aggressive, with metastatic and mortality rates up to 30%, as well as an associated high risk of recurrence.12 Management generally involves excision with intraoperative margin control and conjunctival mapping biopsies, or Mohs micrographic surgery.

Malignant melanoma

Malignant melanoma account for <1% of all eyelid malignancies.19 The lower eyelid is more commonly involved. Any pigmented lesion that increases in size, has irregular borders or multiple colors or is associated with ulcerating and bleeding warrants further investigation.

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